Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release.

Wang, Sheng; Yu, Guocan; Wang, Zhantong; Jacobson, Orit; Lin, Li-Sen; Yang, Weijing; Deng, Hongzhang; He, Zhimei; Liu, Yuan; Chen, Zhi-Yi; Chen, Xiaoyuan

Wang, Sheng; Yu, Guocan; Wang, Zhantong; Jacobson, Orit; Lin, Li-Sen; Yang, Weijing; Deng, Hongzhang; He, Zhimei; Liu, Yuan; Chen, Zhi-Yi; Chen, Xiaoyuan.

Afiliação

Wang S; Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, The Liwan Hospital of the Third Affiliated Hospital of, Guangzhou Medical University, Guangzhou, Guangdong, 510000, China.
Yu G; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Wang Z; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Jacobson O; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Lin LS; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Yang W; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Deng H; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
He Z; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Liu Y; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Chen ZY; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Chen X; Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, The Liwan Hospital of the Third Affiliated Hospital of, Guangzhou Medical University, Guangzhou, Guangdong, 510000, China.

Angew Chem Int Ed Engl ; 58(41): 14758-14763, 2019 10 07.

Article em En | MEDLINE | ID: mdl-31429173

Assuntos

Antibióticos Antineoplásicos/química; Doxorrubicina/química; Naftoquinonas/química; Pró-Fármacos; Células A549; Animais; Liberação Controlada de Fármacos; Humanos; Camundongos; Nanopartículas; Neoplasias Experimentais/tratamento farmacológico; Espécies Reativas de Oxigênio

Palavras-chave

Fenton reaction; cancer therapy; drug delivery; nanomedicine; prodrugs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Doxorrubicina / Naftoquinonas / Antibióticos Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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