A modified calcium retention capacity assay clarifies the roles of extra- and intracellular calcium pools in mitochondrial permeability transition pore opening.

Harisseh, Rania; Abrial, Maryline; Chiari, Pascal; Al-Mawla, Ribal; Villedieu, Camille; Tessier, Nolwenn; Bidaux, Gabriel; Ovize, Michel; Gharib, Abdallah

Harisseh, Rania; Abrial, Maryline; Chiari, Pascal; Al-Mawla, Ribal; Villedieu, Camille; Tessier, Nolwenn; Bidaux, Gabriel; Ovize, Michel; Gharib, Abdallah.

Afiliação

Harisseh R; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Abrial M; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Chiari P; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France pascal.chiari@chu-lyon.fr.
Al-Mawla R; Service d'Anesthésie Réanimation, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Villedieu C; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Tessier N; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Bidaux G; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Ovize M; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.
Gharib A; INSERM UMR 1060, CarMeN laboratory, Université Lyon 1, IHU OPERA, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Lyon, France.

J Biol Chem ; 294(42): 15282-15292, 2019 10 18.

Article em En | MEDLINE | ID: mdl-31434742

Assuntos

Cálcio/metabolismo; Mitocôndrias Cardíacas/metabolismo; Proteínas de Transporte da Membrana Mitocondrial/metabolismo; Miócitos Cardíacos/metabolismo; Animais; Morte Celular; Células Cultivadas; Retículo Endoplasmático/metabolismo; Humanos; Hipóxia/metabolismo; Hipóxia/fisiopatologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Poro de Transição de Permeabilidade Mitocondrial; Miócitos Cardíacos/citologia

Palavras-chave

anoxiareoxygenation; caffeine; calcium; cardiac infarction; cardiomyocyte; mitochondria; mitochondrial permeability transition (MPT); ryanodine; ryanodine receptor; sarcoplasmic reticulum (SR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Miócitos Cardíacos / Proteínas de Transporte da Membrana Mitocondrial / Mitocôndrias Cardíacas Limite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França

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