Effect of rutin on retinal VEGF, TNF-&#945;, aldose reductase, and total antioxidant capacity in diabetic rats: molecular mechanism and ocular pharmacokinetics.

Gupta, Suresh Kumar; Sharma, Hanuman Prasad; Das, Ujjalkumar; Velpandian, Thirumurthy; Saklani, Ravi

Effect of rutin on retinal VEGF, TNF-α, aldose reductase, and total antioxidant capacity in diabetic rats: molecular mechanism and ocular pharmacokinetics.

Gupta, Suresh Kumar; Sharma, Hanuman Prasad; Das, Ujjalkumar; Velpandian, Thirumurthy; Saklani, Ravi.

Afiliação

Gupta SK; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Pushp Vihar Sector III, New Delhi, 110017, India. skgup@hotmail.com.
Sharma HP; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Pushp Vihar Sector III, New Delhi, 110017, India.
Das U; Ocular Pharmacology and Pharmacy Division, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.
Velpandian T; Ocular Pharmacology and Pharmacy Division, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.
Saklani R; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Pushp Vihar Sector III, New Delhi, 110017, India.

Int Ophthalmol ; 40(1): 159-168, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31456155

Assuntos

Aldeído Redutase/metabolismo; Antioxidantes/metabolismo; Retinopatia Diabética/prevenção & controle; Retina/metabolismo; Rutina/farmacocinética; Fator de Necrose Tumoral alfa/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Animais; Biomarcadores/metabolismo; Diabetes Mellitus Experimental; Retinopatia Diabética/diagnóstico; Retinopatia Diabética/metabolismo; Feminino; Angiofluoresceinografia/métodos; Fundo de Olho; Masculino; Ratos; Ratos Wistar; Retina/patologia

Palavras-chave

Diabetes; Ocular; Pharmacokinetics; Retinopathy; Rutin; VEGF

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Rutina / Fator de Necrose Tumoral alfa / Aldeído Redutase / Fator A de Crescimento do Endotélio Vascular / Retinopatia Diabética / Antioxidantes Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Int Ophthalmol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia

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