Your browser doesn't support javascript.
loading
Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia.
Villacampa, Pilar; Liyanage, Sidath E; Klaska, Izabela P; Cristante, Enrico; Menger, Katja E; Sampson, Robert D; Barlow, Maeve; Abelleira-Hervas, Laura; Duran, Yanai; Smith, Alexander J; Ali, Robin R; Luhmann, Ulrich F O; Bainbridge, James W B.
Afiliação
  • Villacampa P; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Liyanage SE; Bellvitge Biomedical Research Institute (IDIBELL), Duran i Reynals Hospital, Gran Via de L´Hospitalet 199-203, 08908, Hospitalet de Llobregat, Spain.
  • Klaska IP; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Cristante E; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Menger KE; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Sampson RD; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Barlow M; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Abelleira-Hervas L; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Duran Y; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Smith AJ; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Ali RR; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Luhmann UFO; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
  • Bainbridge JWB; Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
Angiogenesis ; 23(2): 83-90, 2020 05.
Article em En | MEDLINE | ID: mdl-31583505
ABSTRACT
The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascular regeneration but exacerbated by pathological neovascularization. Aberrant growth of neovessels in the retina is responsible for impairment of sight in common blinding disorders including retinopathy of prematurity, proliferative diabetic retinopathy, and age-related macular degeneration. Myeloid cells are key players in this process, with diverse roles that can either promote or protect against ocular neovascularization. We have previously demonstrated that myeloid-derived VEGF, HIF1, and HIF2 are not essential for pathological retinal neovascularization. Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Vasos Retinianos / Células Mieloides / Proteína Supressora de Tumor Von Hippel-Lindau / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Subunidade alfa do Fator 1 Induzível por Hipóxia / Isquemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Angiogenesis Assunto da revista: HEMATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Vasos Retinianos / Células Mieloides / Proteína Supressora de Tumor Von Hippel-Lindau / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Subunidade alfa do Fator 1 Induzível por Hipóxia / Isquemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Angiogenesis Assunto da revista: HEMATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido