Crystal structures of <i>Babesia microti</i> lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.

Yu, Long; Shen, Zhou; Liu, Qin; Zhan, Xueyan; Luo, Xiaoyin; An, Xiaomeng; Sun, Yali; Li, Muxiao; Wang, Sen; Nie, Zheng; Ao, Yangsiqi; Zhao, Yangnan; Peng, Guiqing; Mamoun, Choukri Ben; He, Lan; Zhao, Junlong

Crystal structures of Babesia microti lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.

Yu, Long; Shen, Zhou; Liu, Qin; Zhan, Xueyan; Luo, Xiaoyin; An, Xiaomeng; Sun, Yali; Li, Muxiao; Wang, Sen; Nie, Zheng; Ao, Yangsiqi; Zhao, Yangnan; Peng, Guiqing; Mamoun, Choukri Ben; He, Lan; Zhao, Junlong.

Afiliação

Yu L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Shen Z; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Liu Q; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zhan X; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Luo X; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
An X; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Sun Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Li M; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Wang S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Nie Z; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Ao Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zhao Y; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
Peng G; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Mamoun CB; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.
He L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zhao J; Key Laboratory of Preventive Veterinary Medicine, Wuhan, China.

FASEB J ; 33(12): 13669-13682, 2019 12.

Article em En | MEDLINE | ID: mdl-31585506

Assuntos

Arginina/metabolismo; Babesia microti/enzimologia; Proteínas de Bactérias/química; Proteínas de Bactérias/metabolismo; L-Lactato Desidrogenase/química; L-Lactato Desidrogenase/metabolismo; Arginina/química; Babesia microti/efeitos dos fármacos; Babesia microti/crescimento & desenvolvimento; Proteínas de Bactérias/genética; Catálise; Anticoncepcionais Masculinos/farmacologia; Cristalografia por Raios X; Gossipol/farmacologia; L-Lactato Desidrogenase/genética; Modelos Moleculares; Compostos Orgânicos/farmacologia; Conformação Proteica; Especificidade por Substrato

Palavras-chave

LDH; babesiosis; catalytic mechanism; growth inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Proteínas de Bactérias / Babesia microti / L-Lactato Desidrogenase Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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