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GSDMD membrane pore is critical for IL-1ß release and antagonizing IL-1ß by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis.
Luan, Jingyun; Chen, Wei; Fan, Jiajun; Wang, Shaofei; Zhang, Xuyao; Zai, Wenjing; Jin, Xin; Wang, Yichen; Feng, Zhenyi; Zhang, Jinghui; Liu, Ming-Lin; Ju, Dianwen.
Afiliação
  • Luan J; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Chen W; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Fan J; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Wang S; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of P
  • Zhang X; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of P
  • Zai W; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Jin X; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Wang Y; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Feng Z; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China.
  • Zhang J; Department of Gastrointestinal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China.
  • Liu ML; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Corporal Michael J. Crescenz VAMC, Philadelphia, PA, 19104, USA. Electronic address: lium1@pennmedicine.upenn.edu.
  • Ju D; Department of Microbiological and Biochemical Pharmacy& the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China; Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai, 201199, China. Electronic address: dianwenju@fu
Biomaterials ; 227: 119570, 2020 01.
Article em En | MEDLINE | ID: mdl-31670032
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-1beta / Fígado Gorduroso Alcoólico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-1beta / Fígado Gorduroso Alcoólico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China