Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.

Bekeova, Carmen; Anderson-Pullinger, Lauren; Boye, Kevin; Boos, Felix; Sharpadskaya, Yana; Herrmann, Johannes M; Seifert, Erin L

Bekeova, Carmen; Anderson-Pullinger, Lauren; Boye, Kevin; Boos, Felix; Sharpadskaya, Yana; Herrmann, Johannes M; Seifert, Erin L.

Afiliação

Bekeova C; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Anderson-Pullinger L; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Boye K; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Boos F; Division of Cellular Biology, Department of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany.
Sharpadskaya Y; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Herrmann JM; Division of Cellular Biology, Department of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany.
Seifert EL; MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 erin.seifert@jefferson.edu.

J Biol Chem ; 294(50): 19034-19047, 2019 12 13.

Article em En | MEDLINE | ID: mdl-31676684

Assuntos

Acil Coenzima A/metabolismo; Mitocôndrias/enzimologia; Palmitoil-CoA Hidrolase/metabolismo; Animais; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias/metabolismo; Palmitoil-CoA Hidrolase/deficiência; Palmitoil-CoA Hidrolase/genética; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Especificidade por Substrato; Tioléster Hidrolases/metabolismo

Palavras-chave

acyl-CoA thioesterase (Acot); allosteric regulation; coenzyme A (CoA); enzyme compartmentalization; fatty acid oxidation; lipid hydrolase; lipid metabolism; long-chain acyl-CoA regulation; mitochondria; mitochondrial matrix; mitochondrial metabolism; mouse; subcellular localization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitoil-CoA Hidrolase / Acil Coenzima A / Mitocôndrias Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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