BDNF and NGF signals originating from sensory ganglia promote cranial motor axon growth.
Exp Brain Res
; 238(1): 111-119, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31802149
ABSTRACT
After exiting the hindbrain, branchial motor axons reach their targets in association with sensory ganglia. The trigeminal ganglion has been shown to promote motor axon growth from rhombomeres 2/3 and 4/5, but it is unknown whether this effect is ganglion specific and through which signals it is mediated. Here, we addressed these questions by co-cultures of ventral rhombomere 8 explants with cranial and spinal sensory ganglia in a collagen gel matrix. Our results show that all cranial sensory ganglia and even a trunk dorsal root ganglion can promote motor axon growth and that ganglia isolated from older embryos had a stronger effect on the axonal growth than younger ones. We found that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are necessary and sufficient for this effect. Altogether, our results demonstrate that the promoting effect of sensory ganglia on cranial motor axon growth is stage dependent, but not ganglion specific and is mediated by BDNF and NGF signals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Gânglios Sensitivos
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Fator Neurotrófico Derivado do Encéfalo
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Nervos Cranianos
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Fator de Crescimento Neural
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Neurônios Motores
Limite:
Animals
Idioma:
En
Revista:
Exp Brain Res
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha