Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007.

Liu, Ran; Fang, Fang; An, Ziheng; Huang, Renqiong; Wang, Yong; Sun, Xiao; Fu, Shuai; Fu, Aisi; Deng, Zixin; Liu, Tiangang

Liu, Ran; Fang, Fang; An, Ziheng; Huang, Renqiong; Wang, Yong; Sun, Xiao; Fu, Shuai; Fu, Aisi; Deng, Zixin; Liu, Tiangang.

Afiliação

Liu R; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Fang F; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
An Z; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Huang R; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Wang Y; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Sun X; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Fu S; J1 Biotech Co., Ltd, Wuhan, 430075, China.
Fu A; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Deng Z; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Liu T; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

J Ind Microbiol Biotechnol ; 47(2): 275-285, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31853778

Assuntos

Actinomycetales/genética; Antibacterianos/metabolismo; Lactonas/metabolismo; Família Multigênica; Actinomycetales/metabolismo; Genômica; Engenharia Metabólica/métodos

Palavras-chave

Biosynthetic gene cluster; Maduramicin; Metabolic engineering; Polyether; Thioesterase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinomycetales / Família Multigênica / Lactonas / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Revista: J Ind Microbiol Biotechnol Assunto da revista: BIOTECNOLOGIA / MICROBIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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