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Olfactory dysfunction correlates with putaminal dopamine turnover in early de novo Parkinson's disease.
Löhle, Matthias; Wolz, Martin; Beuthien-Baumann, Bettina; Oehme, Liane; van den Hoff, Jörg; Kotzerke, Jörg; Reichmann, Heinz; Storch, Alexander.
Afiliação
  • Löhle M; Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147, Rostock, Germany. matthias.loehle@med.uni-rostock.de.
  • Wolz M; German Centre for Neurodegenerative Diseases (DZNE) Rostock, 18147, Rostock, Germany. matthias.loehle@med.uni-rostock.de.
  • Beuthien-Baumann B; Department of Neurology, Elblandklinikum Meißen, Meissen, Germany.
  • Oehme L; Department of Nuclear Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
  • van den Hoff J; Positron Emission Tomography Division, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
  • Kotzerke J; Department of Nuclear Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
  • Reichmann H; Positron Emission Tomography Division, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
  • Storch A; Department of Nuclear Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
J Neural Transm (Vienna) ; 127(1): 9-16, 2020 01.
Article em En | MEDLINE | ID: mdl-31863171
ABSTRACT
Although olfactory dysfunction is one of the most well-established prodromal symptoms in Parkinson's disease (PD), its correlation with clinical disease progression or dopaminergic dysfunction still remains unclear. We here evaluated the association of striatal dopamine metabolism and olfactory function in a homogenous cohort of 30 patients with early untreated de novo PD. Striatal dopamine metabolism was assessed by the extended 18Fluorodopa PET scanning protocol to measure 18Fluorodopa uptake (Kocc) and the effective dopamine distribution volume ratio (EDVR) as the inverse of dopamine turnover. Olfactory function was estimated by the "Sniffin' Sticks" test including odor threshold (T), discrimination (D) and identification (I) assessment. We detected moderate correlations of the EDVR in the posterior putamen with the TDI composite score (r = 0.412; p = 0.024; Pearson's correlation test) and the odor identification score (r = 0.444; p = 0.014). These correlations were confirmed by multivariate regression analyses using age, sex, symptom duration and disease severity as measured by UPDRSIII motor score as candidate covariates. No other associations were observed between olfaction measures and Kocc and EDVR in all striatal regions. Together, olfactory dysfunction in early PD is not correlated with striatal 18Fluorodopa uptake as a measure for dopaminergic degeneration, but with putaminal dopamine turnover as a marker for dopaminergic presynaptic compensatory processes in early PD. These results should be treated as hypothesis generating and require confirmation by larger multicenter studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Putamen / Dopamina / Transtornos do Olfato Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neural Transm (Vienna) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Putamen / Dopamina / Transtornos do Olfato Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neural Transm (Vienna) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha