IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease.

Low, Lauretta D; Lu, Liangjian; Chan, Chang-Yien; Chen, Jinmiao; Yang, Henry H; Yu, Hanry; Lee, Caroline G L; Ng, Kar-Hui; Yap, Hui-Kim

Low, Lauretta D; Lu, Liangjian; Chan, Chang-Yien; Chen, Jinmiao; Yang, Henry H; Yu, Hanry; Lee, Caroline G L; Ng, Kar-Hui; Yap, Hui-Kim.

Afiliação

Low LD; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Lu L; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore 119260, Singapore.
Chan CY; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore 119260, Singapore.
Chen J; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Yang HH; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore 119260, Singapore.
Yu H; Bioinformatics, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.
Lee CGL; Cancer Science Institute of Singapore & Department of Biochemistry, National University of Singapore, Singapore 117599, Singapore.
Ng KH; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Yap HK; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Clin Sci (Lond) ; 134(2): 225-237, 2020 01 31.

Article em En | MEDLINE | ID: mdl-31934720

Assuntos

Colesterol/metabolismo; Hipercolesterolemia/metabolismo; Interleucina-13/metabolismo; Fígado/metabolismo; Nefrose Lipoide/metabolismo; Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo; Animais; Colesterol/sangue; Modelos Animais de Doenças; Regulação para Baixo; Hipercolesterolemia/sangue; Hipercolesterolemia/complicações; Lipoproteínas/metabolismo; Receptores X do Fígado/metabolismo; Masculino; Nefrose Lipoide/sangue; Nefrose Lipoide/complicações; Pró-Proteína Convertase 9/metabolismo; Proteinúria/complicações; Proteinúria/metabolismo; Ratos Wistar; Proteínas de Ligação a Elemento Regulador de Esterol/metabolismo

Palavras-chave

Abcg5; Hypercholesterolemia; Lxra; Pcsk9; interleukin-13; minimal change disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colesterol / Interleucina-13 / Hipercolesterolemia / Fígado / Nefrose Lipoide Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin Sci (Lond) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Singapura

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