Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1ß-Producing Myeloid Cells that Promote Pathogenic T Cells.

McGinley, Aoife M; Sutton, Caroline E; Edwards, Sarah C; Leane, Charlotte M; DeCourcey, Joseph; Teijeiro, Ana; Hamilton, John A; Boon, Louis; Djouder, Nabil; Mills, Kingston H G

McGinley, Aoife M; Sutton, Caroline E; Edwards, Sarah C; Leane, Charlotte M; DeCourcey, Joseph; Teijeiro, Ana; Hamilton, John A; Boon, Louis; Djouder, Nabil; Mills, Kingston H G.

Afiliação

McGinley AM; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Sutton CE; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Edwards SC; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Leane CM; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
DeCourcey J; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Teijeiro A; Molecular Oncology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid 28029, Spain.
Hamilton JA; Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia.
Boon L; Bioceros, Utrecht, the Netherlands.
Djouder N; Molecular Oncology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid 28029, Spain.
Mills KHG; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: kingston.mills@tcd.ie.

Immunity ; 52(2): 342-356.e6, 2020 02 18.

Article em En | MEDLINE | ID: mdl-32023490

Assuntos

Autoimunidade/imunologia; Interleucina-17/imunologia; Interleucina-1beta/metabolismo; Linfócitos Intraepiteliais/imunologia; Células Mieloides/imunologia; Células Th17/imunologia; Animais; Autoantígenos/imunologia; Autoimunidade/genética; Sistema Nervoso Central/imunologia; Encefalomielite Autoimune Experimental/genética; Encefalomielite Autoimune Experimental/imunologia; Interleucina-17/antagonistas & inibidores; Interleucina-17/deficiência; Interleucina-17/metabolismo; Interleucina-1beta/imunologia; Interleucina-23/imunologia; Interleucina-23/metabolismo; Linfócitos Intraepiteliais/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Monócitos/imunologia; Monócitos/metabolismo; Células Mieloides/metabolismo; Neutrófilos/imunologia; Neutrófilos/metabolismo; Células Th17/metabolismo

Palavras-chave

IL-17; IL-1ß; Th17 cells; autoimmunity; experimental autoimmune encephalomyelitis; inflammatory monocyte; multiple sclerosis; neutrophil; Î³Î´ T cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoimunidade / Interleucina-17 / Células Mieloides / Interleucina-1beta / Células Th17 / Linfócitos Intraepiteliais Limite: Animals Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Irlanda

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