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The associations of CYP19A1 rs700518 polymorphism with bone mineral density and risk of osteoporosis: a meta-analysis.
Ma, Hua-Jing; Fu, Suo-Chao; Xiao, An; Cai, Wen-Ke; Wang, Ping; Shen, Ming-Li; Li, Zhi-Yue; He, Gong-Hao.
Afiliação
  • Ma HJ; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
  • Fu SC; Department of Orthopaedics, General Hospital of South Theatre, Guangzhou, China.
  • Xiao A; Department of Infectious Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
  • Cai WK; Department of Cardio-Thoracic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming, China.
  • Wang P; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
  • Shen ML; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
  • Li ZY; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
  • He GH; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
Gynecol Endocrinol ; 36(7): 626-631, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32070153
Osteoporosis is now a worldwide public health problem that seriously endangers human health, but its causes have not yet been fully clarified. Recently, increasing evidence suggested that polymorphisms in CYP19A1 gene were associated with osteoporosis risk and bone mineral density (BMD), but results remained conflicting. We herein performed a meta-analysis based on evidence currently available from the literature to make a more precise estimation of these relationships. The PubMed, Embase, Cochrane library, CNKI (China National Knowledge Infrastructure), and Wan Fang databases were searched for eligible studies. Odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) were applied to assess the strength of these relationships. A total of 8 studies involving 2632 subjects were included in our meta-analysis. We observed that the AG genotype of CYP19A1 rs700518 was significantly associated with lower BMD values of lumbar spine and femoral neck (AG vs. GG: p = .001 and.01, respectively). However, this polymorphism had no obvious impacts on osteoporosis risk according to current available data. In conclusion, the present meta-analysis showed that CYP19A1 rs700518 polymorphism may be a potential candidate biomarker for osteoporosis screening, early diagnosis, and treatment, which will help improve individualized therapy of osteoporosis patients in clinics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Aromatase / Densidade Óssea Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Aromatase / Densidade Óssea Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China