mTORC1-dependent protein synthesis and autophagy uncouple in the regulation of Apolipoprotein A-I expression.

Georgila, Konstantina; Gounis, Michalis; Havaki, Sophia; Gorgoulis, Vassilis G; Eliopoulos, Aristides G

Georgila, Konstantina; Gounis, Michalis; Havaki, Sophia; Gorgoulis, Vassilis G; Eliopoulos, Aristides G.

Afiliação

Georgila K; Laboratory of Molecular and Cellular Biology, University of Crete Medical School, Heraklion, Crete, Greece; Department of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Gounis M; Laboratory of Molecular and Cellular Biology, University of Crete Medical School, Heraklion, Crete, Greece.
Havaki S; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece; Faculty Institute for Cancer Sciences
Eliopoulos AG; Department of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. Electronic address: eliopag@med.uoa.gr.

Metabolism ; 105: 154186, 2020 04.

Article em En | MEDLINE | ID: mdl-32084429

Assuntos

Apolipoproteína A-I/biossíntese; Autofagia/genética; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Animais; Apolipoproteína A-I/genética; Colesterol/metabolismo; Dieta Hiperlipídica; Regulação da Expressão Gênica; Células Hep G2; Hepatócitos/metabolismo; Humanos; Metabolismo dos Lipídeos; Alvo Mecanístico do Complexo 1 de Rapamicina/antagonistas & inibidores; Camundongos; Hepatopatia Gordurosa não Alcoólica/genética; Estado Nutricional; Complexo de Endopeptidases do Proteassoma/genética

Palavras-chave

ApoA-I; Autophagy; mTORC1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Apolipoproteína A-I / Alvo Mecanístico do Complexo 1 de Rapamicina Limite: Animals / Humans Idioma: En Revista: Metabolism Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Grécia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google