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A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.
Konen, Lyndsey M; Wright, Amanda L; Royle, Gordon A; Morris, Gary P; Lau, Benjamin K; Seow, Patrick W; Zinn, Raphael; Milham, Luke T; Vaughan, Christopher W; Vissel, Bryce.
Afiliação
  • Konen LM; Centre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
  • Wright AL; St Vincent's Centre for Applied Medical Research, Sydney, 2011, Australia.
  • Royle GA; Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.
  • Morris GP; Middlemore Hospital, Counties Manukau DHB, Otahuhu, Auckland, 1062, New Zealand.
  • Lau BK; The University of Auckland, Faculty of Medical and Health Sciences, School of Medicine, Grafton, Auckland, 1023, New Zealand.
  • Seow PW; Centre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
  • Zinn R; St Vincent's Centre for Applied Medical Research, Sydney, 2011, Australia.
  • Milham LT; Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, 2065, Australia.
  • Vaughan CW; Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, 2065, Australia.
  • Vissel B; Centre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
Mol Brain ; 13(1): 27, 2020 02 27.
Article em En | MEDLINE | ID: mdl-32102661
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Edição de RNA / Receptores de AMPA / Espinhas Dendríticas / Região CA1 Hipocampal / Aprendizagem / Transtornos da Memória / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Brain Assunto da revista: BIOLOGIA MOLECULAR / CEREBRO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Edição de RNA / Receptores de AMPA / Espinhas Dendríticas / Região CA1 Hipocampal / Aprendizagem / Transtornos da Memória / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Brain Assunto da revista: BIOLOGIA MOLECULAR / CEREBRO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália