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Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) F.H. Chen That Function in Treatment of Hyperlipidemia and Obesity.
Wang, Qian; Mu, Rong-Fang; Liu, Xing; Zhou, Hui-Min; Xu, Yu-Hui; Qin, Wan-Ying; Yang, Chong-Ren; Wang, Li-Bin; Li, Hai-Zhou; Xiong, Wen-Yong.
Afiliação
  • Wang Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China.
  • Mu RF; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Liu X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China.
  • Zhou HM; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Xu YH; Center for Pharmaceutical Sciences, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming, Yunnan 650500, People's Republic of China.
  • Qin WY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China.
  • Yang CR; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Wang LB; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China.
  • Li HZ; School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, People's Republic of China.
  • Xiong WY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China.
J Agric Food Chem ; 68(17): 4865-4875, 2020 Apr 29.
Article em En | MEDLINE | ID: mdl-32306731
Saponins of Panax notoginseng (Burk.) F.H. Chen have been classified as a type of composition in functional foods for numerous diseases. However, its mild effects and other characteristics limited clinical applications in diseases. Inspired by "nine steaming and nine processing" of P. notoginseng in traditional Chinese medicine, we developed a "steaming"-mimic protocol, which significantly changed the composition of saponins of P. notoginseng from the original, R1, Rg1, Re, Rb1, and Rd (raw-PNS), to the products after steaming, 20S/R-Rh1, Rk3, Rh4, 20S/R-Rg3, Rk1, and Rg5 (N-PNS). Surprisingly, N-PNS demonstrated promising activities in improving hyperlipidemia and reducing body weight and weight of white adipose tissue and the inhibition of adipogenesis in obese mice. In accordance with the results in vivo, N-PNS remarkably blunted adipogenesis at the early stage of differentiation dose-dependently in vitro. Moreover, we demonstrated that the activity may involve the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway by promoting phosphorylation of AMPKT172 and downregulating its downstream factors: sterol regulatory element binding protein 1c, stearoyl-CoA desaturase 1, and fatty acid synthase. Taken together, the steaming-induced eight compositions of saponins showed a very promising function in improving hyperlipidemia and obesity both in vivo and in vitro, providing fundamental evidence for future study and application in treatment of hyperlipidemia, obesity, and other lipid-related metabolic syndromes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Medicamentos de Ervas Chinesas / Panax notoginseng / Hiperlipidemias / Obesidade Tipo de estudo: Guideline Limite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Medicamentos de Ervas Chinesas / Panax notoginseng / Hiperlipidemias / Obesidade Tipo de estudo: Guideline Limite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Ano de publicação: 2020 Tipo de documento: Article