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High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition.
Ou, Arnold; Schmidberger, Jason W; Wilson, Katie A; Evans, Cameron W; Hargreaves, Jessica A; Grigg, Melanie; O'Mara, Megan L; Iyer, K Swaminathan; Bond, Charles S; Smith, Nicole M.
Afiliação
  • Ou A; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Schmidberger JW; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Wilson KA; Research School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia.
  • Evans CW; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Hargreaves JA; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Grigg M; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • O'Mara ML; Research School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia.
  • Iyer KS; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Bond CS; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
  • Smith NM; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Nucleic Acids Res ; 48(10): 5766-5776, 2020 06 04.
Article em En | MEDLINE | ID: mdl-32313953
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Regiões Promotoras Genéticas / Quadruplex G Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Regiões Promotoras Genéticas / Quadruplex G Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália