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Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders.
Ciarrusta, Judit; Dimitrova, Ralica; Batalle, Dafnis; O'Muircheartaigh, Jonathan; Cordero-Grande, Lucilio; Price, Anthony; Hughes, Emer; Kangas, Johanna; Perry, Emily; Javed, Ayesha; Demilew, Jill; Hajnal, Joseph; Edwards, Anthony David; Murphy, Declan; Arichi, Tomoki; McAlonan, Grainne.
Afiliação
  • Ciarrusta J; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Dimitrova R; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • Batalle D; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • O'Muircheartaigh J; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • Cordero-Grande L; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Price A; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • Hughes E; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Kangas J; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • Perry E; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, United Kingdom.
  • Javed A; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Demilew J; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Hajnal J; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Edwards AD; Centre for the Developing Brain, School Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom.
  • Murphy D; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • Arichi T; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
  • McAlonan G; Dept. of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AB, United Kingdom.
Transl Psychiatry ; 10(1): 131, 2020 05 06.
Article em En | MEDLINE | ID: mdl-32376820
Studies in animal models of autism spectrum disorders (ASD) suggest atypical early neural activity is a core vulnerability mechanism which alters functional connectivity and predisposes to dysmaturation of neural circuits. However, underlying biological changes associated to ASD in humans remain unclear. Results from functional connectivity studies of individuals diagnosed with ASD are highly heterogeneous, in part because of complex life-long secondary and/or compensatory events. To minimize these confounds and examine primary vulnerability mechanisms, we need to investigate very early brain development. Here, we tested the hypothesis that brain functional connectivity is altered in neonates who are vulnerable to this condition due to a family history of ASD. We acquired high temporal resolution multiband resting state functional magnetic resonance imaging (fMRI) in newborn infants with and without a first-degree relative with ASD. Differences in local functional connectivity were quantified using regional homogeneity (ReHo) analysis and long-range connectivity was assessed using distance correlation analysis. Neonates who have a first-degree relative with ASD had significantly higher ReHo within multiple resting state networks in comparison to age matched controls; there were no differences in long range connectivity. Atypical local functional activity may constitute a biomarker of vulnerability, that might precede disruptions in long range connectivity reported in older individuals diagnosed with ASD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Infant / Newborn Idioma: En Revista: Transl Psychiatry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Infant / Newborn Idioma: En Revista: Transl Psychiatry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido