Collateral fitness effects of mutations.

Mehlhoff, Jacob D; Stearns, Frank W; Rohm, Dahlia; Wang, Buheng; Tsou, Erh-Yeh; Dutta, Nisita; Hsiao, Meng-Hsuan; Gonzalez, Courtney E; Rubin, Alan F; Ostermeier, Marc

Mehlhoff, Jacob D; Stearns, Frank W; Rohm, Dahlia; Wang, Buheng; Tsou, Erh-Yeh; Dutta, Nisita; Hsiao, Meng-Hsuan; Gonzalez, Courtney E; Rubin, Alan F; Ostermeier, Marc.

Afiliação

Mehlhoff JD; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Stearns FW; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Rohm D; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Wang B; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Tsou EY; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Dutta N; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Hsiao MH; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Gonzalez CE; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Rubin AF; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Ostermeier M; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.

Proc Natl Acad Sci U S A ; 117(21): 11597-11607, 2020 05 26.

Article em En | MEDLINE | ID: mdl-32385156

Assuntos

Evolução Molecular; Aptidão Genética/genética; Mutação de Sentido Incorreto/genética; Mutação de Sentido Incorreto/fisiologia; Escherichia coli/enzimologia; Escherichia coli/genética; Escherichia coli/fisiologia; Proteínas de Escherichia coli/química; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; beta-Lactamases/química; beta-Lactamases/genética; beta-Lactamases/metabolismo

Palavras-chave

beta-lactamase; fitness landscape; protein aggregation; protein evolution; stress response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Molecular / Mutação de Sentido Incorreto / Aptidão Genética Tipo de estudo: Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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