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Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile.
Zhou, Hui-Min; Ye, Yan-Song; Jiang, Na-Na; Mu, Rong-Fang; Wang, Qian; Hu, Jing; Liu, Xia; Qin, Wan-Ying; Xu, Gang; Xiong, Wen-Yong.
Afiliação
  • Zhou HM; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • Ye YS; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Jiang NN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • Mu RF; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Wang Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • Hu J; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Liu X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • Qin WY; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Xu G; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • Xiong WY; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Nat Prod Bioprospect ; 10(3): 163-170, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32447748
Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Bioprospect Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Bioprospect Ano de publicação: 2020 Tipo de documento: Article