Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment.
Int J Mol Sci
; 21(11)2020 May 29.
Article
em En
| MEDLINE
| ID: mdl-32486027
ABSTRACT
The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-ß (TGF-ß) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various diseases, including cancer, which can arise as a consequence of dysregulated BMP signaling. Mutations in crucial elements of this signaling pathway, such as receptors, have been reported to disrupt BMP signaling. Next to that, aberrant expression of BMP antagonists could also contribute to abrogated signaling. In this review we set out to highlight how BMP antagonists affect not only the cancer cells, but also the other cells present in the microenvironment to influence cancer progression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Proteínas Morfogenéticas Ósseas
/
Microambiente Tumoral
/
Mutação
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Holanda