MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5.
Pharmazie
; 75(6): 275-278, 2020 06 01.
Article
em En
| MEDLINE
| ID: mdl-32539925
ABSTRACT
MicroRNAs (miRNAs) play important roles in the progression of acute lung injury (ALI). So far, little is known about the role of miR-520c-3p in ALI. In this study, the mechanism of the occurrence and development of ALI was explored. We firstly found that miR-520c-3p could inhibit the expression of NLRC5. A549 cells were treated with lipopolysaccharide (LPS) in vitro to simulate ALI cells and inducing ALI model mice. Moreover, miR-520c-3p overexpression enhanced the viability of damaged cells, inhibited LPS-induced apoptosis, and decreased LPS-induced IL-1ß, IL-6 and TNF-α. In addition, the NLRC5 was a direct target of miR-520c-3p. And NLRC5 partially aggravated inflammation injury. In conclusion, miR-520c-3p alleviates LPS-induced inflammatory injury via regulating NLRC5.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
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Peptídeos e Proteínas de Sinalização Intracelular
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Lesão Pulmonar Aguda
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Inflamação
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China