Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO-101 in adult male and female volunteers.

Bergmann, Troels K; Stage, Tore B; Stenvang, Jan; Christophersen, Palle; Jacobsen, Thomas A; Roest, Nicklas L; Vestlev, Peter M; Brünner, Nils

Bergmann, Troels K; Stage, Tore B; Stenvang, Jan; Christophersen, Palle; Jacobsen, Thomas A; Roest, Nicklas L; Vestlev, Peter M; Brünner, Nils.

Afiliação

Bergmann TK; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Stage TB; Hospital Pharmacy, Hospital of South West Jutland, Esbjerg, Denmark.
Stenvang J; OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.
Christophersen P; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Jacobsen TA; Scandion Oncology A/S, Copenhagen, Denmark.
Roest NL; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Vestlev PM; Saniona A/S, Ballerup, Denmark.
Brünner N; Saniona A/S, Ballerup, Denmark.

Basic Clin Pharmacol Toxicol ; 127(4): 329-337, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32628359

Assuntos

Antineoplásicos/administração & dosagem; Antineoplásicos/efeitos adversos; Antineoplásicos/farmacocinética; Canais de Cloreto/antagonistas & inibidores; Administração Oral; Adulto; Antineoplásicos/sangue; Área Sob a Curva; Estudos de Coortes; Método Duplo-Cego; Feminino; Voluntários Saudáveis; Humanos; Masculino; Farmacocinética

Palavras-chave

cancer chemotherapy; development; discovery and development; drug; drug discovery; drug discovery and development; pharmacokinetics; safety evaluation; safety pharmacology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cloreto / Antineoplásicos Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Basic Clin Pharmacol Toxicol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca

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