Regulatory noncoding RNAs and the major histocompatibility complex.
Hum Immunol
; 82(7): 532-540, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-32636038
ABSTRACT
The Major Histocompatibility Complex (MHC) is a 4 Mbp genomic region located on the short arm of chromosome 6. The MHC region contains many key immune-related genes such as Human Leukocyte Antigens (HLAs). There has been a growing realization that, apart from MHC encoded proteins, RNAs derived from noncoding regions of the MHC-specifically microRNAs (miRNAs) and long noncoding RNAs (lncRNAs)-play a significant role in cellular regulation. Furthermore, regulatory noncoding RNAs (ncRNAs) derived from other parts of the genome fine-tune the expression of many immune-related MHC proteins. Although the field of ncRNAs of the MHC is a research area that is still in its infancy, ncRNA regulation of MHC genes has already been shown to be vital for immune function, healthy pregnancy and cellular homeostasis. Dysregulation of this intricate network of ncRNAs can lead to serious perturbations in homeostasis and subsequent disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
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RNA Longo não Codificante
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Complexo Principal de Histocompatibilidade
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos