Cystine-glutamate antiporter xCT as a therapeutic target for cancer.
Cell Biochem Funct
; 39(2): 174-179, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-32749001
ABSTRACT
Cystine/glutamic acid reverse transporter (System Xc - ), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against oxidative stress and ferroptosis. Studies have confirmed that xCT is highly expressed in a variety of tumour and is associated with tumour proliferation, invasion, metastasis, drug resistance and ferroptosis, and can be used as a potential target for tumour treatment. This review provides insights into the biological effects of xCT and contribute to the development of new xCT-based strategies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema y/ de Transporte de Aminoácidos
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Cell Biochem Funct
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China