Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.

Tillman, Matthew C; Imai, Norihiro; Li, Yue; Khadka, Manoj; Okafor, C Denise; Juneja, Puneet; Adhiyaman, Akshitha; Hagen, Susan J; Cohen, David E; Ortlund, Eric A

Tillman, Matthew C; Imai, Norihiro; Li, Yue; Khadka, Manoj; Okafor, C Denise; Juneja, Puneet; Adhiyaman, Akshitha; Hagen, Susan J; Cohen, David E; Ortlund, Eric A.

Afiliação

Tillman MC; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Imai N; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065.
Li Y; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Khadka M; Emory Integrated Lipidomics Core, Emory University, Atlanta, GA 30322.
Okafor CD; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Juneja P; Robert P. Apkarian Integrated Electron Microscopy Core, Emory University, Atlanta, GA 30322.
Adhiyaman A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Hagen SJ; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Cohen DE; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065.
Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322; eortlun@emory.edu.

Proc Natl Acad Sci U S A ; 117(36): 22080-22089, 2020 09 08.

Article em En | MEDLINE | ID: mdl-32820071

Assuntos

Ácidos Graxos/metabolismo; Lisofosfatidilcolinas/metabolismo; Palmitoil-CoA Hidrolase/química; Palmitoil-CoA Hidrolase/metabolismo; Acil Coenzima A/metabolismo; Tecido Adiposo Marrom/enzimologia; Tecido Adiposo Marrom/metabolismo; Regulação Alostérica; Ácidos Graxos/química; Humanos; Cinética; Gotículas Lipídicas/enzimologia; Gotículas Lipídicas/metabolismo; Lisofosfatidilcolinas/química; Palmitoil-CoA Hidrolase/genética; Domínios Proteicos

Palavras-chave

STARD14; START domain; fatty acids; lysophosphatidylcholine; thermogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitoil-CoA Hidrolase / Lisofosfatidilcolinas / Ácidos Graxos Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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