Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.
Science
; 370(6514): 314-321, 2020 10 16.
Article
em En
| MEDLINE
| ID: mdl-32855216
ABSTRACT
The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial colonization than duodenal neurons. Specifically, a microbially responsive subset of viscerofugal CART+ neurons, enriched in the ileum and colon, modulated feeding and glucose metabolism. These CART+ neurons send axons to the prevertebral ganglia and are polysynaptically connected to the liver and pancreas. Microbiota depletion led to NLRP6- and caspase 11-dependent loss of CART+ neurons and impaired glucose regulation. Hence, iEAN subsets appear to be capable of regulating blood glucose levels independently from the central nervous system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Colo
/
Microbioma Gastrointestinal
/
Gânglios Simpáticos
/
Íleo
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2020
Tipo de documento:
Article