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Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Barlaam, Bernard; Boiko, Scott; Boyd, Scott; Dry, Hannah; Gingipalli, Lakshmaiah; Ikeda, Timothy; Johnson, Tony; Kawatkar, Sameer; Lorthioir, Olivier; Pike, Andy; Pollard, Hannah; Read, Jon; Su, Qibin; Wang, Haiyun; Wang, Huimin; Wang, Lianghe; Wang, Peng; Edmondson, Scott D.
Afiliação
  • Barlaam B; R&D Oncology, AstraZeneca, Cambridge, United Kingdom. Electronic address: Bernard.barlaam2@astrazeneca.com.
  • Boiko S; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Boyd S; R&D Oncology, AstraZeneca, Cambridge, United Kingdom.
  • Dry H; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Gingipalli L; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Ikeda T; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Johnson T; R&D Oncology, AstraZeneca, Cambridge, United Kingdom.
  • Kawatkar S; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Lorthioir O; R&D Oncology, AstraZeneca, Cambridge, United Kingdom.
  • Pike A; R&D Oncology, AstraZeneca, Cambridge, United Kingdom.
  • Pollard H; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
  • Read J; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
  • Su Q; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Wang H; R&D Oncology, AstraZeneca, Boston, MA, United States.
  • Wang H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, PR China.
  • Wang L; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, PR China.
  • Wang P; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, PR China.
  • Edmondson SD; R&D Oncology, AstraZeneca, Boston, MA, United States.
Bioorg Med Chem Lett ; 30(22): 127523, 2020 11 15.
Article em En | MEDLINE | ID: mdl-32877741
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Quinase Syk Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Quinase Syk Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article