Your browser doesn't support javascript.
loading
Genetic variants of TAS2R38 bitter taste receptor associate with distinct gut microbiota traits in Parkinson's disease: A pilot study.
Vascellari, Sarah; Melis, Melania; Cossu, Giovanni; Melis, Marta; Serra, Alessandra; Palmas, Vanessa; Perra, Daniela; Oppo, Valentina; Fiorini, Michele; Cusano, Roberto; Morelli, Micaela; Manzin, Aldo; Barbarossa, Iole Tomassini.
Afiliação
  • Vascellari S; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: svascellari@unica.it.
  • Melis M; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: melaniamelis@unica.it.
  • Cossu G; Department of Neurology AO Brotzu, Cagliari, Italy. Electronic address: giovannicossu1@gmail.com.
  • Melis M; Department of Neurology AOU Policlinico 'D. Casula' Monserrato, Cagliari, Italy. Electronic address: mrtmelis@gmail.com.
  • Serra A; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: aleserra@unica.it.
  • Palmas V; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: vanessapalmas@hotmail.it.
  • Perra D; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: daniperra@unica.it.
  • Oppo V; Department of Neurology AO Brotzu, Cagliari, Italy. Electronic address: valentinaoppo@gmail.com.
  • Fiorini M; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy. Electronic address: michele.fiorini@univr.it.
  • Cusano R; CRS4, Science and Technology Park Polaris, Piscina Manna, Pula, Cagliari, Italy. Electronic address: robycuso@crs4.it.
  • Morelli M; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: morelli@unica.it.
  • Manzin A; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: aldomanzin@unica.it.
  • Barbarossa IT; Department of Biomedical Sciences, University of Cagliari, Italy. Electronic address: tomassin@unica.it.
Int J Biol Macromol ; 165(Pt A): 665-674, 2020 Dec 15.
Article em En | MEDLINE | ID: mdl-32946938
ABSTRACT
The non-tasting form of the bitter taste receptor, TAS2R38, has been shown as a genetic risk factor associated with the development of Parkinson's disease (PD). Specific taste receptors that are expressed in the lower gastrointestinal tract may respond to alteration in gut microbiota composition, detecting bacterial molecules, and regulate immune responses. Given the importance of brain-gut-microbiota axis and gene-environment interactions in PD, we investigate the associations between the genetic variants of TAS2R38 and gut microbiota composition in 39 PD patients. The results confirm that the majority of PD patients have reduced sensitivity to 6-n-propylthiouracil (PROP) and are carriers of at least one non-functional TAS2R38 AVI haplotype. Moreover, we found this correlation to be associated with a reduction in bacteria alpha-diversity with a predominant reduction of Clostridium genus. We hypothesised that the high frequency of the non-taster form of TAS2R38 associated with a diminuition of Clostridium bacteria in PD might determine a reduction in the activation of protective signalling-molecules useful in preserving gut homeostasis. This pilot study, by identifying a decrease in specific bacteria associated with a reduced sensitivity to PROP, adds essential information that opens new avenues of research into the association of PD microbiota composition and sensory modification.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Variação Genética / Clostridium / Receptores Acoplados a Proteínas G / Microbioma Gastrointestinal Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Variação Genética / Clostridium / Receptores Acoplados a Proteínas G / Microbioma Gastrointestinal Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article