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A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?
Rakipovski, Günaj; Rolin, Bidda; Barascuk, Natasha; Lund, Heidi Engslev; Bjørn Bonde, Mathilde Frederikke; Djordjevic, Djordje; Wulff-Larsen, Pernille Gry; Petersen, Maj; Kirk, Rikke Kaae; Hultman, Karin; Manfe, Valentina; Blume, Niels; Zahn, Stefan; Lengquist, Mariette; Maegdefessel, Lars; Hovingh, G Kees; Conde-Knape, Karin; Hedin, Ulf; Matic, Ljubica; Nyberg, Michael.
Afiliação
  • Rakipovski G; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Rolin B; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Barascuk N; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Lund HE; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Bjørn Bonde MF; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Djordjevic D; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
  • Wulff-Larsen PG; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
  • Petersen M; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Kirk RK; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Hultman K; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Manfe V; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
  • Blume N; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Zahn S; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
  • Lengquist M; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  • Maegdefessel L; Department of Medicine, Karolinska Institute, Stockholm, Sweden; Technical University of Munich, Klinikum Rechts der Isar, Department for Vascular and Endovascular Surgery, Munich, Germany.
  • Hovingh GK; Chief Medical Office, Novo Nordisk A/S, Soeborg, Denmark; Department of Vascular Medicine, Academisch Medisch Centrum, Amsterdam, Netherlands.
  • Conde-Knape K; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
  • Hedin U; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  • Matic L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  • Nyberg M; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark. Electronic address: znyb@novonordisk.com.
Atherosclerosis ; 314: 1-9, 2020 12.
Article em En | MEDLINE | ID: mdl-33129080
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Atherosclerosis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Atherosclerosis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca