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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.
Gnanapradeepan, Keerthana; Leu, Julia I-Ju; Basu, Subhasree; Barnoud, Thibaut; Good, Madeline; Lee, Joyce V; Quinn, William J; Kung, Che-Pei; Ahima, Rexford; Baur, Joseph A; Wellen, Kathryn E; Liu, Qin; Schug, Zachary T; George, Donna L; Murphy, Maureen E.
Afiliação
  • Gnanapradeepan K; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • Leu JI; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Basu S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Barnoud T; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • Good M; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • Lee JV; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • Quinn WJ; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Kung CP; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Ahima R; Washington University in St. Louis, St Louis, United States.
  • Baur JA; Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of Medicine, Baltimore, United States.
  • Wellen KE; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Liu Q; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Schug ZT; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • George DL; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
  • Murphy ME; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Elife ; 92020 11 10.
Article em En | MEDLINE | ID: mdl-33170774
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Serina-Treonina Quinases TOR Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Serina-Treonina Quinases TOR Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos