Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via &#945;-2 Adrenergic Receptor.

Sun, Mingyang; Dong, Yuanlin; Li, Mengzhu; Zhang, Yiying; Liang, Feng; Zhang, Jiaqiang; Soriano, Sulpicio G; Xie, Zhongcong

Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor.

Sun, Mingyang; Dong, Yuanlin; Li, Mengzhu; Zhang, Yiying; Liang, Feng; Zhang, Jiaqiang; Soriano, Sulpicio G; Xie, Zhongcong.

Afiliação

Sun M; From the Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Dong Y; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Li M; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Zhang Y; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Liang F; Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Zhang J; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Soriano SG; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Xie Z; From the Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Anesth Analg ; 132(3): 878-889, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33181559

Assuntos

Agonistas de Receptores Adrenérgicos alfa 2/farmacologia; Comportamento Animal/efeitos dos fármacos; Clonidina/farmacologia; Cognição/efeitos dos fármacos; Disfunção Cognitiva/prevenção & controle; Dexmedetomidina/farmacologia; Hipocampo/efeitos dos fármacos; Receptores Adrenérgicos alfa 2/efeitos dos fármacos; Proteínas tau/metabolismo; Fatores Etários; Animais; Disfunção Cognitiva/induzido quimicamente; Disfunção Cognitiva/metabolismo; Disfunção Cognitiva/psicologia; Modelos Animais de Doenças; Comportamento Exploratório/efeitos dos fármacos; Feminino; Hipocampo/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Teste do Labirinto Aquático de Morris/efeitos dos fármacos; Fosforilação; Receptores Adrenérgicos alfa 2/metabolismo; Sevoflurano

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Clonidina / Proteínas tau / Cognição / Receptores Adrenérgicos alfa 2 / Dexmedetomidina / Agonistas de Receptores Adrenérgicos alfa 2 / Disfunção Cognitiva / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Anesth Analg Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google