Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1.

Chuan, Libo; Huang, Xin; Fan, Chuming; Wen, Shiyuan; Yang, Xiaohua; Wang, Jingrong; Ren, Jingyu; Ru, Jin; Ding, Li

Chuan, Libo; Huang, Xin; Fan, Chuming; Wen, Shiyuan; Yang, Xiaohua; Wang, Jingrong; Ren, Jingyu; Ru, Jin; Ding, Li.

Afiliação

Chuan L; Faculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming, 650500, China; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: 70745503@qq.com.
Huang X; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: cc2vivi@qq.com.
Fan C; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: fanchuming@sina.com.
Wen S; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: shiyuanwen267@126.com.
Yang X; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: yangxiaohua200819@163.com.
Wang J; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: 529334553@qq.com.
Ren J; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: kmrenjy@163.com.
Ru J; ICU, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: rujin227@163.com.
Ding L; Faculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming, 650500, China; Department of Neurology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: dongliiid@163.com.

Eur J Pharmacol ; 891: 173716, 2021 Jan 15.

Article em En | MEDLINE | ID: mdl-33197442

Assuntos

Encéfalo/efeitos dos fármacos; Reanimação Cardiopulmonar/efeitos adversos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Proteínas de Choque Térmico/metabolismo; Hipóxia Encefálica/prevenção & controle; Metformina/farmacologia; Proteína 1 de Ligação a X-Box/metabolismo; Animais; Apoptose/efeitos dos fármacos; Encéfalo/metabolismo; Encéfalo/patologia; Citoproteção; Modelos Animais de Doenças; Proteínas de Choque Térmico/genética; Hipóxia Encefálica/etiologia; Hipóxia Encefálica/metabolismo; Hipóxia Encefálica/patologia; Masculino; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitocôndrias/patologia; Estresse Oxidativo/efeitos dos fármacos; Ratos Sprague-Dawley; Transdução de Sinais; Proteína 1 de Ligação a X-Box/genética

Palavras-chave

Cardiac arrest; Endoplasmic reticulum stress; GRP78; Metformin; XBP1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Hipóxia Encefálica / Reanimação Cardiopulmonar / Estresse do Retículo Endoplasmático / Proteína 1 de Ligação a X-Box / Proteínas de Choque Térmico / Metformina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2021 Tipo de documento: Article

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