Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy.

Sheta, Razan; Bachvarova, Magdalena; Plante, Marie; Renaud, Marie-Claude; Sebastianelli, Alexandra; Gregoire, Jean; Navarro, Jamilet Miranda; Perez, Ricardo Bringas; Masson, Jean-Yves; Bachvarov, Dimcho

Sheta, Razan; Bachvarova, Magdalena; Plante, Marie; Renaud, Marie-Claude; Sebastianelli, Alexandra; Gregoire, Jean; Navarro, Jamilet Miranda; Perez, Ricardo Bringas; Masson, Jean-Yves; Bachvarov, Dimcho.

Afiliação

Sheta R; Department of Molecular Medicine, Université Laval, Québec, QC, G1V 0A6, Canada.
Bachvarova M; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.
Plante M; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.
Renaud MC; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.
Sebastianelli A; Department of Obstetrics and Gynecology, Université Laval, Québec, QC, G1V 0A6, Canada.
Gregoire J; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.
Navarro JM; Department of Obstetrics and Gynecology, Université Laval, Québec, QC, G1V 0A6, Canada.
Perez RB; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.
Masson JY; Department of Obstetrics and Gynecology, Université Laval, Québec, QC, G1V 0A6, Canada.
Bachvarov D; Centre de recherche du CHU de Québec, Oncology division, L'Hôtel-Dieu de Québec, 9 rue McMahon, Québec, QC, G1R 3S3, Canada.

J Transl Med ; 18(1): 439, 2020 11 19.

Article em En | MEDLINE | ID: mdl-33213473

Assuntos

Neoplasias Ovarianas; Inibidores de Poli(ADP-Ribose) Polimerases; Adenosina Difosfato Ribose/uso terapêutico; Biomarcadores; Carcinoma Epitelial do Ovário/tratamento farmacológico; Carcinoma Epitelial do Ovário/genética; Feminino; Humanos; Neoplasias Ovarianas/tratamento farmacológico; Neoplasias Ovarianas/genética; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico

Palavras-chave

3D cellular model; Ascites; Biomarkers; Epithelial-to-mesenchymal transition; Functional assay; High-grade serous ovarian cancer; PARP inhibitors homologous recombination repair pathway; Primary cell cultures; Spheroids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Inibidores de Poli(ADP-Ribose) Polimerases Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: J Transl Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá

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