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Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme.
Kaczmarski, Joe A; Mahawaththa, Mithun C; Feintuch, Akiva; Clifton, Ben E; Adams, Luke A; Goldfarb, Daniella; Otting, Gottfried; Jackson, Colin J.
Afiliação
  • Kaczmarski JA; Research School of Chemistry, The Australian National University, Canberra, ACT, 2601, Australia.
  • Mahawaththa MC; Research School of Chemistry, The Australian National University, Canberra, ACT, 2601, Australia.
  • Feintuch A; Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, 76100, Israel.
  • Clifton BE; Research School of Chemistry, The Australian National University, Canberra, ACT, 2601, Australia.
  • Adams LA; Protein Engineering and Evolution Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Okinawa, 904-0412, Japan.
  • Goldfarb D; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Otting G; Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, 76100, Israel. daniella.goldfarb@weizmann.ac.il.
  • Jackson CJ; Research School of Chemistry, The Australian National University, Canberra, ACT, 2601, Australia. gottfried.otting@anu.edu.au.
Nat Commun ; 11(1): 5945, 2020 11 23.
Article em En | MEDLINE | ID: mdl-33230119
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Molecular / Enzimas Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Molecular / Enzimas Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália