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Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease.
Krumm, Sabine; Berres, Manfred; Kivisaari, Sasa L; Monsch, Andreas U; Reinhardt, Julia; Blatow, Maria; Kressig, Reto W; Taylor, Kirsten I.
Afiliação
  • Krumm S; University Department of Geriatric Medicine FELIX PLATTER, Basel, Switzerland.
  • Berres M; Faculty of Medicine, University of Basel, Basel, Switzerland.
  • Kivisaari SL; Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, Germany.
  • Monsch AU; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto, Finland.
  • Reinhardt J; University Department of Geriatric Medicine FELIX PLATTER, Basel, Switzerland.
  • Blatow M; Faculty of Medicine, University of Basel, Basel, Switzerland.
  • Kressig RW; Faculty of Psychology, University of Basel, Basel, Switzerland.
  • Taylor KI; Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Arch Clin Neuropsychol ; 36(5): 838-843, 2021 Jul 19.
Article em En | MEDLINE | ID: mdl-33237317
ABSTRACT

OBJECTIVE:

Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls.

METHOD:

Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures.

RESULTS:

Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals.

CONCLUSION:

Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Semântica / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Arch Clin Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Semântica / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Arch Clin Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça