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The immune landscape in tuberculosis reveals populations linked to disease and latency.
Esaulova, Ekaterina; Das, Shibali; Singh, Dhiraj Kumar; Choreño-Parra, Jose Alberto; Swain, Amanda; Arthur, Laura; Rangel-Moreno, Javier; Ahmed, Mushtaq; Singh, Bindu; Gupta, Ananya; Fernández-López, Luis Alejandro; de la Luz Garcia-Hernandez, Maria; Bucsan, Allison; Moodley, Chivonne; Mehra, Smriti; García-Latorre, Ethel; Zuniga, Joaquin; Atkinson, Jeffrey; Kaushal, Deepak; Artyomov, Maxim N; Khader, Shabaana A.
Afiliação
  • Esaulova E; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Das S; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Singh DK; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  • Choreño-Parra JA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Laboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City
  • Swain A; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Arthur L; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Rangel-Moreno J; Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Ahmed M; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Singh B; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  • Gupta A; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Fernández-López LA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Laboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City
  • de la Luz Garcia-Hernandez M; Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Bucsan A; Tulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
  • Moodley C; Tulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
  • Mehra S; Tulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
  • García-Latorre E; Laboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07320, Mexico.
  • Zuniga J; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City 07320 Mexico.
  • Atkinson J; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Kaushal D; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. Electronic address: dkaushal@txbiomed.org.
  • Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.
  • Khader SA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: sakhader@wustl.edu.
Cell Host Microbe ; 29(2): 165-178.e8, 2021 02 10.
Article em En | MEDLINE | ID: mdl-33340449
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects approximately one-fourth of the world's population. The immune mechanisms that govern progression from latent (LTBI) to active pulmonary TB (PTB) remain poorly defined. Experimentally Mtb-infected non-human primates (NHP) mirror the disease observed in humans and recapitulate both PTB and LTBI. We characterized the lung immune landscape in NHPs with LTBI and PTB using high-throughput technologies. Three defining features of PTB in macaque lungs include the influx of plasmacytoid dendritic cells (pDCs), an Interferon (IFN)-responsive macrophage population, and activated T cell responses. In contrast, a CD27+ Natural killer (NK) cell subset accumulated in the lungs of LTBI macaques. This NK cell population was also detected in the circulation of LTBI individuals. This comprehensive analysis of the lung immune landscape will improve the understanding of TB immunopathogenesis, providing potential targets for therapies and vaccines for TB control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Células Dendríticas / Células Matadoras Naturais / Tuberculose Latente / Macrófagos / Mycobacterium tuberculosis Limite: Animals / Humans Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Células Dendríticas / Células Matadoras Naturais / Tuberculose Latente / Macrófagos / Mycobacterium tuberculosis Limite: Animals / Humans Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos