Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt-Jakob Disease Patients.

Areskeviciute, Ausrine; Litman, Thomas; Broholm, Helle; Melchior, Linea C; Nielsen, Pia R; Green, Alison; Eriksen, Jens O; Smith, Colin; Lund, Eva L

Areskeviciute, Ausrine; Litman, Thomas; Broholm, Helle; Melchior, Linea C; Nielsen, Pia R; Green, Alison; Eriksen, Jens O; Smith, Colin; Lund, Eva L.

Afiliação

Areskeviciute A; Department of Pathology, Danish Reference Center for Prion Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Litman T; Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Broholm H; Department of Pathology, Danish Reference Center for Prion Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Melchior LC; Department of Pathology, Danish Reference Center for Prion Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Nielsen PR; Department of Surgical Pathology, Zealand University Hospital, 4000 Roskilde, Denmark.
Green A; National Creutzfeldt-Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh EH8 9AB, UK.
Eriksen JO; Department of Surgical Pathology, Zealand University Hospital, 4000 Roskilde, Denmark.
Smith C; National Creutzfeldt-Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh EH8 9AB, UK.
Lund EL; Department of Pathology, Danish Reference Center for Prion Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark.

Int J Mol Sci ; 22(1)2020 Dec 25.

Article em En | MEDLINE | ID: mdl-33375642

Assuntos

Biomarcadores; Encéfalo/metabolismo; Síndrome de Creutzfeldt-Jakob/etiologia; Síndrome de Creutzfeldt-Jakob/metabolismo; Expressão Gênica; Idoso; Encéfalo/patologia; Microambiente Celular/genética; Microambiente Celular/imunologia; Biologia Computacional/métodos; Síndrome de Creutzfeldt-Jakob/patologia; Suscetibilidade a Doenças; Feminino; Perfilação da Expressão Gênica; Humanos; Masculino; Pessoa de Meia-Idade; Transcriptoma

Palavras-chave

CreutzfeldtJakob disease; biomarkers; brain microenvironment; gene expression analysis; immune response; microglia; neuroinflammation; prion disease; regional pathogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Biomarcadores / Expressão Gênica / Síndrome de Creutzfeldt-Jakob Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca

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