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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Matheson, Christopher J; Coxon, Christopher R; Bayliss, Richard; Boxall, Kathy; Carbain, Benoit; Fry, Andrew M; Hardcastle, Ian R; Harnor, Suzannah J; Mas-Droux, Corine; Newell, David R; Richards, Mark W; Sivaprakasam, Mangaleswaran; Turner, David; Griffin, Roger J; Golding, Bernard T; Cano, Céline.
Afiliação
  • Matheson CJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Coxon CR; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Bayliss R; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
  • Boxall K; Section of Structural Biology , The Institute of Cancer Research , Sutton , UK.
  • Carbain B; Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , Sutton , UK.
  • Fry AM; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Hardcastle IR; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
  • Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Mas-Droux C; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Newell DR; Section of Structural Biology , The Institute of Cancer Research , Sutton , UK.
  • Richards MW; Cancer Research UK Newcastle Drug Discovery Unit , Translational and Clinical Research Institute , Newcastle University Centre for Cancer , Faculty of Medical Sciences , Newcastle University , Newcastle upon Tyne , UK.
  • Sivaprakasam M; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
  • Turner D; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Golding BT; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
  • Cano C; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
RSC Med Chem ; 11(6): 707-731, 2020 Jun 01.
Article em En | MEDLINE | ID: mdl-33479670
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Med Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Med Chem Ano de publicação: 2020 Tipo de documento: Article