Your browser doesn't support javascript.
loading
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
Dragovich, Peter S; Pillow, Thomas H; Blake, Robert A; Sadowsky, Jack D; Adaligil, Emel; Adhikari, Pragya; Bhakta, Sunil; Blaquiere, Nicole; Chen, Jinhua; Dela Cruz-Chuh, Josefa; Gascoigne, Karen E; Hartman, Steven J; He, Mingtao; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R; Liu, Liang; Liu, Liling; Liu, Qi; Lu, Ying; Meng, Fanwei; Mulvihill, Melinda M; O'Donohue, Aimee; Rowntree, Rebecca K; Staben, Leanna R; Staben, Steven T; Wai, John; Wang, Jian; Wei, BinQing; Wilson, Catherine; Xin, Jianfeng; Xu, Zijin; Yao, Hui; Zhang, Donglu; Zhang, Hongyan; Zhou, Hao; Zhu, Xiaoyu.
Afiliação
  • Dragovich PS; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Pillow TH; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Blake RA; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sadowsky JD; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Adaligil E; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Adhikari P; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Bhakta S; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Blaquiere N; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Chen J; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Dela Cruz-Chuh J; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gascoigne KE; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Hartman SJ; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • He M; Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China.
  • Kaufman S; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Kleinheinz T; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Kozak KR; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Liu L; Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China.
  • Liu L; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Liu Q; Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China.
  • Lu Y; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Meng F; Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China.
  • Mulvihill MM; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • O'Donohue A; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Rowntree RK; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Staben LR; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Staben ST; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wai J; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Wang J; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Wei B; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wilson C; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Xin J; Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China.
  • Xu Z; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Yao H; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Zhang D; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang H; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Zhou H; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Zhu X; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
J Med Chem ; 64(5): 2534-2575, 2021 03 11.
Article em En | MEDLINE | ID: mdl-33596065
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Imunoconjugados / Proteínas de Ciclo Celular / Dipeptídeos / Proteólise / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Imunoconjugados / Proteínas de Ciclo Celular / Dipeptídeos / Proteólise / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos