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Faropenem reacts with serine and metallo-ß-lactamases to give multiple products.
Lucic, Anka; Hinchliffe, Philip; Malla, Tika R; Tooke, Catherine L; Brem, Jürgen; Calvopiña, Karina; Lohans, Christopher T; Rabe, Patrick; McDonough, Michael A; Armistead, Timothy; Orville, Allen M; Spencer, James; Schofield, Christopher J.
Afiliação
  • Lucic A; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • Hinchliffe P; Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom.
  • Malla TR; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • Tooke CL; Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom.
  • Brem J; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • Calvopiña K; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • Lohans CT; Botterell Hall, Queen's University, Kingston, Ontario, K7L 2V7, Canada. Electronic address: christopher.lohans@queensu.ca.
  • Rabe P; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • McDonough MA; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
  • Armistead T; Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom.
  • Orville AM; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, United Kingdom. Electronic address: allen.orville@diamond.ac.uk.
  • Spencer J; Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom. Electronic address: jim.spencer@bristol.ac.uk.
  • Schofield CJ; Chemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk.
Eur J Med Chem ; 215: 113257, 2021 Apr 05.
Article em En | MEDLINE | ID: mdl-33618159
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Beta-Lactamas / Inibidores de beta-Lactamases / Antibacterianos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Beta-Lactamas / Inibidores de beta-Lactamases / Antibacterianos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido