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A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.
Delorey, Toni M; Ziegler, Carly G K; Heimberg, Graham; Normand, Rachelly; Yang, Yiming; Segerstolpe, Asa; Abbondanza, Domenic; Fleming, Stephen J; Subramanian, Ayshwarya; Montoro, Daniel T; Jagadeesh, Karthik A; Dey, Kushal K; Sen, Pritha; Slyper, Michal; Pita-Juárez, Yered H; Phillips, Devan; Bloom-Ackerman, Zohar; Barkas, Nick; Ganna, Andrea; Gomez, James; Normandin, Erica; Naderi, Pourya; Popov, Yury V; Raju, Siddharth S; Niezen, Sebastian; Tsai, Linus T-Y; Siddle, Katherine J; Sud, Malika; Tran, Victoria M; Vellarikkal, Shamsudheen K; Amir-Zilberstein, Liat; Atri, Deepak S; Beechem, Joseph; Brook, Olga R; Chen, Jonathan; Divakar, Prajan; Dorceus, Phylicia; Engreitz, Jesse M; Essene, Adam; Fitzgerald, Donna M; Fropf, Robin; Gazal, Steven; Gould, Joshua; Grzyb, John; Harvey, Tyler; Hecht, Jonathan; Hether, Tyler; Jane-Valbuena, Judit; Leney-Greene, Michael; Ma, Hui.
Afiliação
  • Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Ziegler CGK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Heimberg G; Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA 02115, USA.
  • Normand R; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Yang Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Segerstolpe A; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Abbondanza D; Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.
  • Fleming SJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Subramanian A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Montoro DT; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Jagadeesh KA; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Dey KK; Harvard Medical School, Boston, MA 02115, USA.
  • Sen P; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Pita-Juárez YH; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Phillips D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Bloom-Ackerman Z; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Barkas N; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Ganna A; Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gomez J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Normandin E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Naderi P; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Popov YV; Department of Epidemiology, Harvard School of Public Health.
  • Raju SS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Niezen S; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Tsai LT; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Siddle KJ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Sud M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Tran VM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Vellarikkal SK; Harvard Medical School, Boston, MA 02115, USA.
  • Amir-Zilberstein L; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  • Atri DS; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.
  • Beechem J; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  • Brook OR; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
  • Chen J; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Divakar P; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Dorceus P; Institute for Molecular Medicine Finland, Helsinki, Finland.
  • Engreitz JM; Analytical & Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Essene A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Fitzgerald DM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Fropf R; Harvard Medical School, Boston, MA 02115, USA.
  • Gazal S; Harvard Medical School, Boston, MA 02115, USA.
  • Gould J; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  • Grzyb J; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.
  • Harvey T; Harvard Medical School, Boston, MA 02115, USA.
  • Hecht J; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.
  • Hether T; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Jane-Valbuena J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Leney-Greene M; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Ma H; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
bioRxiv ; 2021 Feb 25.
Article em En | MEDLINE | ID: mdl-33655247

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: BioRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: BioRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos