Simultaneous determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma using UPLC-MS/MS method.

Zheng, Xin; Gao, Huitao; Cui, Xinge; Zhang, Yanbao; Chen, Rui; Wang, Yaqin; Lauruol, Pauline; Wang, Hongyun

Zheng, Xin; Gao, Huitao; Cui, Xinge; Zhang, Yanbao; Chen, Rui; Wang, Yaqin; Lauruol, Pauline; Wang, Hongyun.

Afiliação

Zheng X; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China. Electronic address: zhengxin1@pumch.cn.
Gao H; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China.
Cui X; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China.
Zhang Y; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China.
Chen R; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China.
Wang Y; Servier (Beijing) Pharmaceutical Research & Development CO.,Ltd, China.
Lauruol P; Institut de Recherches Internationales Servier, France.
Wang H; Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Beijing 100032, China. Electronic address: wanghy@pumch.cn.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1169: 122585, 2021 Apr 15.

Article em En | MEDLINE | ID: mdl-33706186

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Indapamida/sangue; Indóis/sangue; Perindopril/sangue; Espectrometria de Massas em Tandem/métodos; Estudos Cross-Over; Combinação de Medicamentos; Humanos; Indapamida/administração & dosagem; Indapamida/química; Indapamida/farmacocinética; Indóis/química; Indóis/farmacocinética; Modelos Lineares; Masculino; Perindopril/administração & dosagem; Perindopril/química; Perindopril/farmacocinética; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Extração em Fase Sólida

Palavras-chave

Human plasma; Hypertension; Indapamide; Method Validation; Perindopril; Perindoprilat; Pharmacokinetics; UPLC-MS/MS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida de Alta Pressão / Perindopril / Espectrometria de Massas em Tandem / Indapamida / Indóis Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans / Male Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article

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