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Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children.
Ahmad, Abdullahi; Prom, Aurelia; Bradley, John; Ndiath, Mamadou; Etoketim, Blessed; Bah, Mamadou; Van Geertruyden, Jean-Pierre; Drakeley, Chris; Bousema, Teun; Achan, Jane; D'Alessandro, Umberto.
Afiliação
  • Ahmad A; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia. aahmad@mrc.gm.
  • Prom A; Global Health Institute, University of Antwerp, Gouverneur Kinsbergencentrum, Campus Drie Eiken, Doornstraat 331, 2610, Wilrijk, Belgium. aahmad@mrc.gm.
  • Bradley J; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia.
  • Ndiath M; MRC Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Etoketim B; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia.
  • Bah M; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia.
  • Van Geertruyden JP; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia.
  • Drakeley C; Global Health Institute, University of Antwerp, Gouverneur Kinsbergencentrum, Campus Drie Eiken, Doornstraat 331, 2610, Wilrijk, Belgium.
  • Bousema T; Department of Immunology and Infection, School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Achan J; Department of Medical Microbiology, Radboud University Medical Center, Geert Grooteplein 28, Microbiology 268, 6500 HB, Nijmegen, The Netherlands.
  • D'Alessandro U; Disease Control and Elimination Theme, Medical Research Council Unit The Gambia At London, School of Hygiene and Tropical Medicine, P.O Box 273, Banjul, The Gambia.
Malar J ; 20(1): 169, 2021 Mar 26.
Article em En | MEDLINE | ID: mdl-33771166
ABSTRACT

BACKGROUND:

Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage. The effect of seasonal malaria chemoprevention (SMC) with SP and AQ on gametocyte carriage was assessed in asymptomatic P. falciparum infected children.

METHODS:

The study was carried out in eastern Gambia. Asymptomatic P. falciparum malaria infected children aged 24-59 months old who were eligible to receive SMC (SMC group) and children 5-8 years that were not eligible to receive SMC (comparison group) were recruited. Gametocytaemia was determined by molecular methods before and after SMC administration. Gametocyte carriage between the groups was compared using the chi-squared test and within-person using conditional logistic regression.

RESULTS:

During the 2017 and 2018 malaria transmission seasons, 65 and 75 children were recruited in the SMC and comparison groups, respectively. Before SMC administration, gametocyte prevalence was 10.7% (7/65) in the SMC group and 13.3% (10/75) in the comparison group (p = 0.64). At day 13 (IQR 12, 13) after SMC administration, this was 9.4% (5/53) in children who received at least the first dose of SMC treatment and 12.7% (9/71) for those in the comparison group (p = 0.57). Similarly, there was no difference in prevalence of gametocytes between children that adhered to all 3-day doses of SMC treatment 15.6% (5/32) and those in the comparison group (p = 0.68). In the SMC group, within-group gametocyte carriage was similar before and after SMC administration in children that received at least the first dose of SMC treatment (OR 0.6, 95% CI 0.14-2.51; p = 0.48) and in those that adhered to all 3-day doses of SMC treatment (OR 1.0, 95% CI 0.20-4.95; p = 1.0).

CONCLUSION:

In this study with relative low gametocyte prevalence prior to SMC treatment, no evidence was observed that SMC treatment increased gametocyte carriage in asymptomatic P. falciparum malaria infected children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Portador Sadio / Malária Falciparum / Quimioprevenção / Infecções Assintomáticas / Antimaláricos Tipo de estudo: Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Portador Sadio / Malária Falciparum / Quimioprevenção / Infecções Assintomáticas / Antimaláricos Tipo de estudo: Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2021 Tipo de documento: Article