A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures.

Majerle, Andreja; Hadzi, San; Aupic, Jana; Satler, Tadej; Lapenta, Fabio; Strmsek, Ziga; Lah, Jurij; Loris, Remy; Jerala, Roman

Majerle, Andreja; Hadzi, San; Aupic, Jana; Satler, Tadej; Lapenta, Fabio; Strmsek, Ziga; Lah, Jurij; Loris, Remy; Jerala, Roman.

Afiliação

Majerle A; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Hadzi S; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Aupic J; Department of Physical Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Satler T; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Lapenta F; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Strmsek Z; Graduate Study Program, Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Lah J; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Loris R; Department of Synthetic Biology and Immunology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
Jerala R; Department of Physical Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia.

Proc Natl Acad Sci U S A ; 118(17)2021 04 27.

Article em En | MEDLINE | ID: mdl-33893235

Assuntos

Conformação Proteica em alfa-Hélice/fisiologia; Engenharia de Proteínas/métodos; Anticorpos de Domínio Único/química; Dimerização; Modelos Moleculares; Peptídeos/química; Polímeros/metabolismo; Conformação Proteica em alfa-Hélice/genética; Domínios Proteicos/genética; Domínios Proteicos/fisiologia; Dobramento de Proteína; Multimerização Proteica; Proteínas/química; Anticorpos de Domínio Único/metabolismo

Palavras-chave

coiled-coil dimer; coiled-coil protein origami; nanobody; protein assembly; protein design

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Anticorpos de Domínio Único / Conformação Proteica em alfa-Hélice Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Eslovênia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google