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Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs.
Mancek-Keber, Mateja; Hafner-Bratkovic, Iva; Lainscek, Dusko; Bencina, Mojca; Govednik, Tea; Orehek, Sara; Plaper, Tjasa; Jazbec, Vid; Bergant, Valter; Grass, Vincent; Pichlmair, Andreas; Jerala, Roman.
Afiliação
  • Mancek-Keber M; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Hafner-Bratkovic I; Centre of Excellence EN-FIST, Ljubljana, Slovenia.
  • Lainscek D; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Bencina M; Centre of Excellence EN-FIST, Ljubljana, Slovenia.
  • Govednik T; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Orehek S; Centre of Excellence EN-FIST, Ljubljana, Slovenia.
  • Plaper T; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Jazbec V; Centre of Excellence EN-FIST, Ljubljana, Slovenia.
  • Bergant V; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Grass V; Graduate School of Biomedicine, University of Ljubljana, Ljubljana, Slovenia.
  • Pichlmair A; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Jerala R; Graduate School of Biomedicine, University of Ljubljana, Ljubljana, Slovenia.
FASEB J ; 35(6): e21651, 2021 06.
Article em En | MEDLINE | ID: mdl-34004056
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Ácido Ascórbico / Compostos de Sulfidrila / Auranofina / Dissulfetos / Ésteres / Internalização do Vírus / Glicoproteína da Espícula de Coronavírus / Amidas / SARS-CoV-2 Limite: Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Eslovênia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Ácido Ascórbico / Compostos de Sulfidrila / Auranofina / Dissulfetos / Ésteres / Internalização do Vírus / Glicoproteína da Espícula de Coronavírus / Amidas / SARS-CoV-2 Limite: Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Eslovênia