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The why behind the high: determinants of neurocognition during acute cannabis exposure.
Ramaekers, Johannes G; Mason, Natasha L; Kloft, Lilian; Theunissen, Eef L.
Afiliação
  • Ramaekers JG; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands. j.ramaekers@maastrichtuniversity.nl.
  • Mason NL; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  • Kloft L; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  • Theunissen EL; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Nat Rev Neurosci ; 22(7): 439-454, 2021 07.
Article em En | MEDLINE | ID: mdl-34045693
Acute cannabis intoxication may induce neurocognitive impairment and is a possible cause of human error, injury and psychological distress. One of the major concerns raised about increasing cannabis legalization and the therapeutic use of cannabis is that it will increase cannabis-related harm. However, the impairing effect of cannabis during intoxication varies among individuals and may not occur in all users. There is evidence that the neurocognitive response to acute cannabis exposure is driven by changes in the activity of the mesocorticolimbic and salience networks, can be exacerbated or mitigated by biological and pharmacological factors, varies with product formulations and frequency of use and can differ between recreational and therapeutic use. It is argued that these determinants of the cannabis-induced neurocognitive state should be taken into account when defining and evaluating levels of cannabis impairment in the legal arena, when prescribing cannabis in therapeutic settings and when informing society about the safe and responsible use of cannabis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Cannabis / Cognição Limite: Female / Humans / Male Idioma: En Revista: Nat Rev Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Cannabis / Cognição Limite: Female / Humans / Male Idioma: En Revista: Nat Rev Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda