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Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation.
Lavra, Luca; Magi, Fiorenza; Ulivieri, Alessandra; Morgante, Alessandra; Paulis, Marianna; Sala, Luca; Pedrazzini, Matteo; Polisca, Patrizio; Rocchetti, Marcella; Calò, Leonardo; Sciacchitano, Salvatore; Salehi, Leila B.
Afiliação
  • Lavra L; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy. Electronic address: luca.lavra@fondazioneniccolocusano.it.
  • Magi F; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy.
  • Ulivieri A; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy.
  • Morgante A; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy.
  • Paulis M; Humanitas Clinical and Research Center-IRCCS, Rozzano, 20089 Milan, Italy; Institute of Genetic and Biomedical Research (IRGB)-UOS of Milan, National Research Council (CNR), 20138 Milan, Italy.
  • Sala L; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Via Zucchi 18, Cusano Milanino, MI, Italy.
  • Pedrazzini M; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Via Zucchi 18, Cusano Milanino, MI, Italy.
  • Polisca P; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy.
  • Rocchetti M; Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.
  • Calò L; Division of Cardiology, Policlinico Casilino, Via Casilina 1049, 00169 Rome, Italy.
  • Sciacchitano S; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
  • Salehi LB; Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy; Medical Genetics Unit, Tor Vergata University Hospital, PTV, Viale Montpellier 1, 00133 Rome, Italy.
Stem Cell Res ; 54: 102418, 2021 07.
Article em En | MEDLINE | ID: mdl-34130155
In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Romano-Ward / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Stem Cell Res Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Romano-Ward / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Stem Cell Res Ano de publicação: 2021 Tipo de documento: Article