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B cell residency but not T cell-independent IgA switching in the gut requires innate lymphoid cells.
Zheng, Mingzhu; Mao, Kairui; Fang, Difeng; Li, Dan; Lyu, Jun; Peng, Dingkang; Chen, Xi; Cannon, Nikki; Hu, Gangqing; Han, Jiajia; Zhao, Keji; Chen, Wanjun; Zhu, Jinfang.
Afiliação
  • Zheng M; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Mao K; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Fang D; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China.
  • Li D; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Lyu J; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Peng D; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, People's Republic of China.
  • Chen X; Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou 215004, People's Republic of China.
  • Cannon N; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Hu G; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, People's Republic of China.
  • Han J; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Zhao K; The Third Xiangya Hospital, Central South University, Changsha 410013, People's Republic of China.
  • Chen W; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
  • Zhu J; Bioinformatics Core, West Virginia University, Morgantown, WV 26506.
Proc Natl Acad Sci U S A ; 118(27)2021 07 06.
Article em En | MEDLINE | ID: mdl-34187897
Immunoglobulin A (IgA)-producing plasma cells derived from conventional B cells in the gut play an important role in maintaining the homeostasis of gut flora. Both T cell-dependent and T cell-independent IgA class switching occurs in the lymphoid structures in the gut, whose formation depends on lymphoid tissue inducers (LTis), a subset of innate lymphoid cells (ILCs). However, our knowledge on the functions of non-LTi helper-like ILCs, the innate counter parts of CD4 T helper cells, in promoting IgA production is still limited. By cell adoptive transfer and utilizing a unique mouse strain, we demonstrated that the generation of IgA-producing plasma cells from B cells in the gut occurred efficiently in the absence of both T cells and helper-like ILCs and without engaging TGF-ß signaling. Nevertheless, B cell recruitment and/or retention in the gut required functional NKp46-CCR6+ LTis. Therefore, while CCR6+ LTis contribute to the accumulation of B cells in the gut through inducing lymphoid structure formation, helper-like ILCs are not essential for the T cell-independent generation of IgA-producing plasma cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Linfócitos B / Linfócitos / Linfócitos T / Switching de Imunoglobulina / Trato Gastrointestinal / Imunidade Inata Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Linfócitos B / Linfócitos / Linfócitos T / Switching de Imunoglobulina / Trato Gastrointestinal / Imunidade Inata Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article