Evolution of master sex determiners: TGF-ß signalling pathways at regulatory crossroads.
Philos Trans R Soc Lond B Biol Sci
; 376(1832): 20200091, 2021 08 30.
Article
em En
| MEDLINE
| ID: mdl-34247498
ABSTRACT
To date, more than 20 different vertebrate master sex-determining genes have been identified on different sex chromosomes of mammals, birds, frogs and fish. Interestingly, six of these genes are transcription factors (Dmrt1- or Sox3- related) and 13 others belong to the TGF-ß signalling pathway (Amh, Amhr2, Bmpr1b, Gsdf and Gdf6). This pattern suggests that only a limited group of factors/signalling pathways are prone to become top regulators again and again. Although being clearly a subordinate member of the sex-regulatory network in mammals, the TGF-ß signalling pathway made it to the top recurrently and independently. Facing this rolling wave of TGF-ß signalling pathways, this review will decipher how the TGF-ß signalling pathways cope with the canonical sex gene regulatory network and challenge the current evolutionary concepts accounting for the diversity of sex-determining mechanisms. This article is part of the theme issue 'Challenging the paradigm in sex chromosome evolution empirical and theoretical insights with a focus on vertebrates (Part I)'.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Sexuais
/
Vertebrados
/
Transdução de Sinais
/
Fator de Crescimento Transformador beta
/
Evolução Molecular
/
Processos de Determinação Sexual
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suíça